Though full of promise, Big Data research success is often contingent on access to the newest, most advanced, and often expensive hardware systems and the expertise needed to build and implement such systems. As a result, the accessibility of the growing number of Big Data-capable technology solutions has often been the preserve of business analytics. Pay as you store/process services like Amazon Web Services have opened up possibilities for smaller scale Big Data projects. There is high demand for this type (...) of research in the digital humanities and digital sociology, for example. However, scholars are increasingly finding themselves at a disadvantage as available data sets of interest continue to grow in size and complexity. Without a large amount of funding or the ability to form interdisciplinary partnerships, only a select few find themselves in the position to successfully engage Big Data. This article identifies several notable and popular Big Data technologies typically implemented using large and extremely powerful cloud-based systems and investigates the feasibility and utility of development of Big Data analytics systems implemented using low-cost commodity hardware in basic and easily maintainable configurations for use within academic social research. Through our investigation and experimental case study, we found that not only are solutions like Cloudera’s Hadoop feasible, but that they can also enable robust, deep, and fruitful research outcomes in a variety of use-case scenarios across the disciplines. (shrink)

This article examines nanotechnology within the context of the public interest. It notes that though nanotechnology research and development investment totalled US$9.6 billion in 2005, the public presently understands neither the implications nor how it might be best governed. The article maps a range of nanotechnology dialogue activities under way within the United Kingdom, the United States, Germany, and Australia. It explores the various approaches to articulating public interest matters and notes a shift in the way in which these governments, (...) on the whole, appear to be attempting to manage nanotechnology “risks.” It argues that open and transparent policy deliberations and extensive public discourse will be pivotal to protecting the public interest, gaining public trust and acceptance of nanotechnologies. The article concludes that though governing emerging technologies in the public interest is not a new concept, nanotechnology does present additional challenges that must be addressed by the guardians of the public interest. (shrink)

Popular culture can play a significant role in shaping the acceptance of evolving technologies, with nanotechnology likely to be a case in point. The most popular fiction work to date in this arena has been Michael Crichton's techno-thriller Prey, which fuses together nanotechnology science with science fiction. Within the context of Prey, this article examines the role that scientists and popular culture play in educating society, and one another, about emerging technologies. In di ferentiating fact from fiction, the article reflects (...) on how such distinctions may be important in proactive public dialogue projects. The article concludes that popular culture will be a key factor in informing citizen beliefs about the coming nano-age. Accordingly, governments, in conjunction with the scientific community, will need to be proactive in distinguishing science fact from science fiction for the benefit of their citizens. (shrink)

Development-oriented funding schemes such as the UK Global Challenges Research Fund (GCRF) have opened up opportunities for collaborations between low-middle income countries (LMICs) and high-income country (HIC) researchers. In particular, funding for medical technology research has seen a rise in previously under-represented disciplines such as physics and engineering. These collaborations have considerable potential to advance healthcare in LMICs, yet can pose challenges experienced to researchers undertaking these collaborations. Key challenges include a lack of tradition of HIC/LMIC collaborations within participating departments, (...) lack of experience with development agendas, designing contextually-appropriate technologies and ensuring long-term viability of research outputs. This paper reflects on these key challenges, using the experiences of the authors on the Open Laboratory Instrumentation (OLI) project as a focalizing lens. This project was a GCRF-funded collaboration between physicists in the UK and engineers in Tanzania to develop an open-source, 3D-printed, fully-automated laboratory microscope. The paper highlights key ethics lessons learnt. (shrink)

There is little doubt that the development and commercialisation of nanotechnologies is challenging traditional state-based regulatory regimes. Yet governments currently appear to be taking a non-interventionist approach to directly regulating this emerging technology. This paper argues that a large regulatory toolbox is available for governing this small technology and that as nanotechnologies evolve, many regulatory advances are likely to occur outside of government. It notes the scientific uncertainties facing us as we contemplate nanotechnology regulatory matters and then examines the notion (...) of regulation itself, suggesting new ways to frame our understanding of both regulation and the regulatory tools relevant to nanotechnologies. By drawing upon three different conceptual lenses of regulation, the paper articulates a wide range of potential regulatory tools at hand. It also focuses particularly on the ways various tools are currently being used or perhaps may be employed in the future. The strengths and weaknesses characterising these tools is examined as well as the different actors involved. The paper concludes that we will increasingly face debate over what is likely to work most effectively in regulating nano technologies, the legitimacy of these different potential approaches, and the speed at which these different regimes may be employed. (shrink)

This essay argues that making a diagnosis in medicine is essentially a hermeneutic enterprise, one in which interpretation skills play a major part in understanding a disease. The clinical encounter is an event comprised of two voices; one is the voice of science which is grounded in empiricism, the other is that of human experience, which is grounded in story-telling and the interpretation of those stories.Using two voices, one from the Diagnostic and Statistical Manual of Mental Disorders-III-Revised, which describes alcohol (...) abuse and alcohol dependence, and the other, that of Claire, a character in Edward Albee's play, A Delicate Balance, who is conversing with her brother-in-law, Tobias, I apply principles from Hans-Georg Gadamer's hermeneutics to the clinical diagnostic process. The essay will demonstrate that we overlook an enormous amount of information about alcoholism by an overreliance on objective data and that our hope for understanding alcoholics is in listening to their voices, and sharing the interpretation of their experiences with them. (shrink)

In a series of recent articles, Robin Jeshion has developed a theory of singular thought which she calls ‘cognitivism’. According to Jeshion, cognitivism offers a middle path between acquaintance theories—which she takes to impose too strong a requirement on singular thought, and semantic instrumentalism—which she takes to impose too weak a requirement. In this article, I raise a series of concerns about Jeshion's theory, and suggest that the relevant data can be accommodated by a version of acquaintance theory that distinguishes (...) unsuccessful thoughts of singular form from successful singular thoughts, and in addition allows for ‘trace-based’ acquaintance. (shrink)

Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

"[T]his is much more than a conventional reference guide. . . . An essential item in any collection that deals with the subject of ethics and public policy." Choice.

Dana Sawyer unpacks the philosophy-spirituality of Huxley, Watts, and Dass (as well as contemporaries, including Mirabai Starr and Richard Rohr) in ways readers will find intriguing, creating an original view of human nature, revealing why this mystical understanding of the world is called "perennial." During the 1960s and '70s, "Perennial Philosophy" was the most popular theory regarding what the world's mystical traditions held in common, and it was touted as the best platform for understanding the nature of human consciousness, (...) including how to expand it therapeutically with meditation, yoga, and psychedelic drugs. Consequently, books by Aldous Huxley, Alan Watts, Huston Smith, Stanislav Grof, Frances Vaughan, Ram Dass, and other Perennialists were widely available and sold like hotcakes. However, during the '80s, their shared perspective fell out of fashion. The Perennial Philosophy Reloaded corrects several common errors while providing a short, up-to-date overview of the general perspective. The goal is to reveal the continued relevance of Perennial Philosophy during this time of psychedelic renaissance, when many are seeking ways to interpret their experiences, with an engaging narrative free of philosophical shop talk. The result is a demonstration of how Perennial Philosophy applies to all who are interested in self-realization. This book will appeal to the millions today who are involved with mindfulness meditation, hatha yoga, Transcendental Meditation, Tibetan Buddhism, Kabbalah, Zen, Sufism, Shamanic drumming, Christian Centering Prayer, or their own DIY approaches to spiritual awakening. (shrink)

Although Aristotle (Metaphysics, Book IV, Chapter 2) was perhaps the first person to consider the part-whole relationship to be a proper subject matter for philosophic inquiry, the Polish logician Stanislow Lesniewski [15] is generally given credit for the first formal treatment of the subject matter in his Mereology.1 Woodger [30] and Tarski [24] made use of a specific adaptation of Lesniewski's work as a basis for a formal theory of physical things and their parts. The term 'calculus of individuals' was (...) introduced by Leonard and Goodman [14] in their presentation of a system very similar to Tarski's adaptation of Lesniewski's Mereology. Contemporaneously with Lesniewski's development of his Mereology, Whitehead [27] and [28] was developing a theory of extensive abstraction based on the two-place predicate, 'x extends over y\ which is the converse of 'x is a part of y\ This system, according to Russell [22], was to have been the fourth volume of their Pήncipia Mathematica, the never-published volume on geometry. Both Lesniewski [15] and Tarski [25] have recognized the similarities between Whitehead's early work and Lesniewski's Mereology. Between the publication of Whitehead's early work and the publication of Process and Reality [29], Theodore de Laguna [7] published a suggestive alternative basis for Whitehead's theory. This led Whitehead, in Process and Reality, to publish a revised form of his theory based on the two-place predicate, 'x is extensionally connected with y\ It is the purpose of this paper to present a calculus of individuals based on this new Whiteheadian primitive predicate. (shrink)

Hanna proposes a version of non-conceptualism he closely associates with Kant. This paper takes issue with his proposal on two fronts. First, there are reasons to dispute whether any version of non-conceptualism can be rightly attributed to Kant. In addition to pointing out passages that conflict with Hanna's interpretation, I also suggest ways in which the Kant of the Opus Postumum could integrate key insights of non-conceptualism into a basically conceptualist framework. In Part Two of the paper, I turn to (...) a more systematically oriented critique of Hanna's nonconceptualism. Drawing on work by Gareth Evans, John McDowell, Sonia Sedivy, and Alva Noë, I argue that conceptualism is in a position to integrate the points which are taken by Hanna to speak most strongly in favor of non-conceptualism. In particular, I argue for the deep compatibility of conceptualism and direct realism. At the same time, I point to what I see as weaknesses in Hanna's defence of non-conceptualism. (shrink)

Can we understand important social issues by studying individual personalities and decisions? Or are societies somehow more than the people in them? Sociologists have long believed that psychology can't explain what happens when people work together in complex modern societies. In contrast, most psychologists and economists believe that if we have an accurate theory of how individuals make choices and act on them, we can explain pretty much everything about social life. Social Emergence takes a new approach to these longstanding (...) questions. Sawyer argues that societies are complex dynamical systems, and that the best way to resolve these debates is by developing the concept of emergence, focusing on multiple levels of analysis - individuals, interactions, and groups - and with a dynamic focus on how social group phenomena emerge from communication processes among individual members. This book makes a unique contribution not only to complex systems research but also to social theory. (shrink)

A collection of papers to illustrate new waves in Philosophy of Language: -/- "Linguistic Puzzles and Semantic Pretence" by B. Armour-Garb & J. Woodbridge; "Minimal Semantics and the Nature of Psychological Evidence" by E. Borg; "A Naturalistic Approach to the Philosophy of Language" by J. Collins; "In Praise of our Linguistic Intuitions" by A. Everett; "Phenomenal Continua and Secondary Properties" by P. Greenough; "Semantic Oughts in Context" by A. Hattiangadi; "Content Force and Semantic Norms" by M. Kolbel; "Linguistic Competence and (...) Propositional Knowledge" by G. Longworth; "Expressives and Beyond" by S. Predelli; "Analyticity in Externalist Languages" by G. Russell ; "Names as Predicates" by S. Sawyer; "The Epistemic Reading of Counterfactual Conditionals" by K. Schulz; "Introduction, Transmission, and the Foundations of Meaning" by J. Speaks. (shrink)

OBJECTIVE: To describe the issues faced, and how they were addressed, by the University of Toronto Critical Care Medicine Program/Joint Centre for Bioethics Task Force on Appropriate Use of Life-Sustaining Treatment. The clinical problem addressed by the Task Force was dealing with requests by patients or substitute decision makers for life-sustaining treatment that their healthcare providers believe is inappropriate. DESIGN: Case study. SETTING: The University of Toronto Joint Centre for Bioethics/Critical Care Medicine Program Task Force on Appropriate Use of Life-Sustaining (...) Treatment. PARTICIPANTS: The 24-member Task Force included physician and nursing leaders from five critical care units, bioethicists, a legal scholar, a health administration expert, a social worker, and a hospital public relations professional. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Our specific lessons learned include a) a policy focus on process; b) use of a negotiation and mediation model, rather than a hospital ethics committee model, for this process; and c) the policy development process is itself a negotiation, so we recommend equal involvement of interested groups including patients, families, and the public. CONCLUSIONS: This article describes the key issues faced by the Task Force while developing its policy. It will provide a useful starting point for other groups developing policy on appropriate use of life-sustaining treatment. (shrink)

The author draws on arguments from contemporary philosophy of mind to provide an argument for sociological collectivism. This argument for nonreductive individualism accepts that only individuals exist but rejects methodological individualism. In Part I, the author presents the argument for nonreductive individualism by working through the implications of supervenience, multiple realizability, and wild disjunction in some detail. In Part II, he extends the argument to provide a defense for social causal laws, and this account of social causation does not require (...) any commitment to intentionality or agency on the part of individuals. (shrink)

This is a defence of the claim that names are predicates with a demonstrative element in their singular use.

This book provides a reconstructive and critical interpretation of Sartre’s mature dialectical ethics. Taken together, as Sartre intended, the posthumously published key texts demonstrate that the ultimate goal of praxis is “integral humanity” and that “making the human” is always possible because the means to humanity can always be invented.

This article focuses on emergence in social systems. The author begins by proposing a new tool to explore the mechanisms of social emergence: multi agent–based computer simulation. He then draws on philosophy of mind to develop an account of social emergence that raises potential problems for the methodological individualism of both social mechanism and of multi agent simulation. He then draws on various complexity concepts to propose a set of criteria whereby one can determine whether a given social mechanism generates (...) emergent properties, in the sense that their explanation cannot be reduced to a mechanistic account of individuals and their interactions. This combined account helps to resolve the competing claims of methodological individualists and social realists. The author’s conclusion is that the scope of mechanistic explanation may be limited due to the extreme complexity of many social systems. Key Words: emergence • mechanism • computer simulation • methodological individualism • social realism. (shrink)

Hegel's doctrines of absolute negativity and 'the Concept' are among his most original contributions to philosophy and they constitute the systematic core of dialectical thought. Brady Bowman explores the interrelations between these doctrines, their implications for Hegel's critical understanding of classical logic and ontology, natural science and mathematics as forms of 'finite cognition', and their role in developing a positive, 'speculative' account of consciousness and its place in nature. As a means to this end, Bowman also re-examines Hegel's (...) relations to Kant and pre-Kantian rationalism, and to key post-Kantian figures such as Jacobi, Fichte and Schelling. His book draws from the breadth of Hegel's writings to affirm a robustly metaphysical reading of the Hegelian project, and will be of great interest to students of Hegel and of German Idealism more generally. (shrink)

The conventionality of simultaneity at distant points is defended partly by reference to Einstein's 1905 paper founding special relativity. His famous light-signaling definition takes the transit time of light in one direction to be equal to that in the other. Conventionalists such as Reichenbach and Grunbaum argue that he could have made them unequal without denying any physical fact. However, Einstein's more detailed treatment in the 1910 Archives des sciences runs counter to this thesis. There he required that the two (...) signal-paths be physically equivalent and thus that whatever the signals travel through have no perturbing affect on their motions. (shrink)